Treffer: On the mechanisms of growth cone locomotion: modeling and computer simulation.
Title:
On the mechanisms of growth cone locomotion: modeling and computer simulation.
Source:
Journal of theoretical biology [J Theor Biol] 1994 Aug 21; Vol. 169 (4), pp. 355-62.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Elsevier Country of Publication: England NLM ID: 0376342 Publication Model: Print Cited Medium: Print ISSN: 0022-5193 (Print) Linking ISSN: 00225193 NLM ISO Abbreviation: J Theor Biol Subsets: MEDLINE
Imprint Name(s):
Publication: Amsterdam : Elsevier
Original Publication: London.
Original Publication: London.
MeSH Terms:
Substance Nomenclature:
0 (Actins)
0 (Macromolecular Substances)
0 (Macromolecular Substances)
Entry Date(s):
Date Created: 19940821 Date Completed: 19941216 Latest Revision: 20041117
Update Code:
20250114
DOI:
10.1006/jtbi.1994.1158
PMID:
7967628
Database:
MEDLINE
Weitere Informationen
In this paper we put forward a model for growth-cone locomotion in which the actin cytoskeleton is represented by a two-dimensional contractile network and the growth-cone membrane is represented by contractile segments coupled with the actin network. Our computer simulation suggests that many mechanisms, such as the actin polymerization and depolymerization, the attachment of actin filaments to the substratum, the transformation of the growth-cone neck into the axon, and the axonal transport, co-operate to generate growth-cone movement.