• Lipid profiling in nontubercul...

Treffer: Lipid profiling in nontuberculous mycobacterial pulmonary disease based on geospatial locations and disease severity.

Title:
Lipid profiling in nontuberculous mycobacterial pulmonary disease based on geospatial locations and disease severity.
Authors:
Kim J; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Kim KS; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Koh J; Department of Pathology, Seoul National University Hospital, Seoul, South Korea.; Laboratory of Immune Regulation in Department of Biomedical Science, Seoul National University College of Medicine, Seoul, South Korea., Na KJ; Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, South Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea., Kim JY; Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Yim JJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea., Cho JY; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.; Kidney Research Institute, Seoul National University Medical Research Center, Seoul, South Korea.; N. Kwak and J.-Y. Cho are co-senior authors., Kwak N; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.; N. Kwak and J.-Y. Cho are co-senior authors.
Source:
ERJ open research [ERJ Open Res] 2026 Jan 26; Vol. 12 (1). Date of Electronic Publication: 2026 Jan 26 (Print Publication: 2026).
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: European Respiratory Society Country of Publication: England NLM ID: 101671641 Publication Model: eCollection Cited Medium: Print ISSN: 2312-0541 (Print) Linking ISSN: 23120541 NLM ISO Abbreviation: ERJ Open Res Subsets: PubMed not MEDLINE
Imprint Name(s):
Original Publication: Sheffield : European Respiratory Society, [2015]-
Entry Date(s):
Date Created: 20260128 Date Completed: 20260128 Latest Revision: 20260128
Update Code:
20260129
PubMed Central ID:
PMC12833683
DOI:
10.1183/23120541.00275-2025
PMID:
41601583
Database:
MEDLINE

Weitere Informationen

Background: The role of lipid profiles in the pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM-PD) remains largely unexplored. This study aimed to identify lipid profile variations across geospatial lung lesions, their reflection in serum relative to disease severity and their diagnostic discriminative ability using lipidomic analysis.
Methods: Lipidomics was performed using hydrophilic interaction liquid chromatography-tandem mass spectrometry on lung tissues and serum samples. 960 lipid species were analysed across geospatial lung lesions (cavity wall, centre of cavity, granuloma, bronchiectasis and normal lungs) and assessed in serum according to disease severity. Python-based machine-learning models in PyCaret were used to classify NTM-PD based on lipidomic signatures.
Results: This study included 23 lung specimens from seven patients with NTM-PD and 332 serum samples comprising 134 patients with NTM-PD, 136 with non-NTM bronchiectasis and 62 healthy controls. Triacylglycerol (TG) levels were elevated in lung lesions affected by NTM-PD, particularly in the centre of the cavity. In serum, TG levels were higher in patients with NTM-PD than controls but decreased in patients with more severe disease, including those with acid-fast bacilli smear positivity, cavitation or higher BACES (body mass index, age, cavity, erythrocyte sedimentation rate and sex) scores. The top five models, developed using lipid species characteristically altered in NTM-PD, effectively discriminated patients with NTM-PD from healthy controls.
Conclusion: TG levels were elevated in lung lesions affected by NTM-PD but decreased in serum as disease severity increased, suggesting TG accumulation in lung tissues. These findings highlighted the role of lipid metabolism in the pathogenesis of NTM-PD.
(Copyright ©The authors 2026.)

Conflict of interest: K.J. Na is a cofounder and stockholder of Portai, Inc. (South Korea), unrelated to this work. N. Kwak is an Associate Editor for ERJ Open Research. The other authors declare no conflicts of interest.