Treffer: [Perinatal depression: a common condition with major implications for women's health].
Title:
[Perinatal depression: a common condition with major implications for women's health].
Transliterated Title:
Dépression périnatale - Une pathologie fréquente, aux enjeux majeurs pour la santé des femmes.
Authors:
Source:
Medecine sciences : M/S [Med Sci (Paris)] 2025 Dec; Vol. 41 (12), pp. 1024-1030. Date of Electronic Publication: 2026 Jan 06.
Publication Type:
Journal Article; Review; English Abstract
Language:
French
Journal Info:
Publisher: EDK Country of Publication: France NLM ID: 8710980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1958-5381 (Electronic) Linking ISSN: 07670974 NLM ISO Abbreviation: Med Sci (Paris) Subsets: MEDLINE
Imprint Name(s):
Publication: <2003->: Paris : EDK
Original Publication: [Paris] : Flammarion, [1985-
Original Publication: [Paris] : Flammarion, [1985-
MeSH Terms:
Depression, Postpartum*/epidemiology , Depression, Postpartum*/therapy , Depression, Postpartum*/diagnosis , Depression, Postpartum*/psychology , Women's Health* , Depression*/epidemiology , Depression*/therapy , Depression*/diagnosis , Pregnancy Complications*/epidemiology , Pregnancy Complications*/psychology , Pregnancy Complications*/therapy , Pregnancy Complications*/diagnosis, Humans ; Female ; Pregnancy ; Risk Factors
References:
Howard LM, Molyneaux E, Dennis C-L, et al. Non-psychotic mental disorders in the perinatal period. Lancet 2014 ; 384 : 1775–88.
Postpartum Depression: Action towards causes and treatment (PACT) consortium. heterogeneity of postpartum depression: a latent class analysis. Lancet Psychiatry 2015 ; 2 : 59–67.
Pawluski JL, Lonstein JS, Fleming AS. The neurobiology of postpartum anxiety and depression. Trends Neurosci. 2017 ; 40 : 106–20.
Tebeka S, Gauld C, Belzeaux R, et al. Major depressive episode and postpartum depression: A network analysis comparison on the IGEDEPP cohort. Eur Psychiatry J Assoc Eur Psychiatr 2023 ; 66 : e51.
Woody CA, Ferrari AJ, Siskind DJ, et al. A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J Affect Disord 2017 ; 219 : 86–92.
Bhat A, Nanda A, Murphy L, et al. A systematic review of screening for perinatal depression and anxiety in community-based settings. Arch Womens Ment Health 2022 ; 25 : 33–49.
Shorey S, Chee CYI, Ng ED, et al. Prevalence and incidence of postpartum depression among healthy mothers: A systematic review and meta-analysis. J Psychiatr Res 2018 ; 104 : 235–48.
Kothari C, Wiley J, Moe A, et al. Maternal depression is not just a problem early on. Public Health 2016 ; 137 : 154–61.
Wikman A, Axfors C, Iliadis SI, et al. Characteristics of women with different perinatal depression trajectories. J Neurosci Res 2020 ; 98 : 1268–82.
Tebeka S, Le Strat Y, De Premorel Higgons A, et al. Prevalence and incidence of postpartum depression and environmental factors: The IGEDEPP cohort. J Psychiatr Res 2021 ; 138 : 366–74.
Qiu W, Hodges TE, Clark EL, et al. Perinatal depression: Heterogeneity of disease and in animal models. Front Neuroendocrinol 2020 ; 59 : 100854.
Meltzer-Brody S, Larsen JT, Petersen L, et al. Adverse life events increase risk for postpartum psychiatric episodes: A population-based epidemiologic study. Depress Anxiety 2018 ; 35 : 160–7.
Yin X, Sun N, Jiang N, et al. Prevalence and associated factors of antenatal depression: Systematic reviews and meta-analyses. Clin Psychol Rev 2021 ; 83 : 101932.
Doncarli A, Tebeka S, Demiguel V, et al. Prévalence de la dépression, de l’anxiété et des idées suicidaires à deux mois post-partum : données de l’Enquête nationale périnatale 2021 en France hexagonale. 2023.
Dlamini LP, Amelia VL, Shongwe MC, et al. Antenatal depression across trimesters as a risk for postpartum depression and estimation of the fraction of postpartum depression attributable to antenatal depression: A systematic review and meta-analysis of cohort studies. Gen Hosp Psychiatry 2023 ; 85 : 35–42.
American Psychiatric Association. DSM-5 : diagnostic and statistical manual of mental disorders, 5th edition. 2013 : 1275 p.
Stewart DE, Vigod S. Postpartum depression. N Engl J Med 2016 ; 375 : 2177–86.
Xiao M, Hu Y, Huang S, et al. Prevalence of suicidal ideation in pregnancy and the postpartum: A systematic review and meta-analysis. J Affect Disord 2022 ; 296 : 322–36.
Xiao M, Fu B, Huang S, et al. Trajectories of perinatal suicidal ideation from early pregnancy to six weeks postpartum and their influencing factors: A prospective longitudinal study. Psychiatry Res 2023 ; 328 : 115467.
Tebeka S, Godin O, Mazer N, et al. Clinical characteristics of bipolar disorders with postpartum depressive onset. Prog. Neuropsychopharmacol. Biol Psychiatry 2021 ; 107 : 110225.
Liu X, Agerbo E, Li J, et al. Depression and anxiety in the postpartum period and risk of bipolar disorder: a danish nationwide register-based cohort study. J Clin Psychiatry 2017 ; 78 : e469–76.
Norhayati MN, Hazlina NHN, Asrenee AR, et al. Magnitude and risk factors for postpartum symptoms: a literature review. J Affect Disord 2015 ; 175 : 34–52.
Landman A, Ngameni EG, Dubreucq M, et al. Postpartum blues: a predictor of postpartum depression, from the IGEDEPP Cohort. Eur Psychiatry J Assoc Eur Psychiatr 2024 ; 67 : e30.
Rezaie-Keikhaie K, Arbabshastan ME, Rafiemanesh H, et al. Systematic review and meta-analysis of the prevalence of the maternity blues in the postpartum period. JOGNN 2020 ; 49 : 127–36.
Perry A, Gordon-Smith K, Di Florio A, Craddock N, et al. Mood episodes in pregnancy and risk of postpartum recurrence in bipolar disorder: The Bipolar Disorder Research Network Pregnancy Study. J Affect Disord 2021 ; 294 : 714–22.
Stewart DE, Vigod SN. Postpartum depression: pathophysiology, treatment, and emerging therapeutics. Annu Rev Med 2019 ; 70 : 183–96.
Tebeka S, Le Strat Y, Dubertret C. Developmental trajectories of pregnant and postpartum depression in an epidemiologic survey. J Affect Disord 2016 ; 203 : 62–8.
Hutchens BF, Kearney J. Risk factors for postpartum depression: an umbrella review. J Midwifery Womens Health 2020 ; 65 : 96–108.
Tebeka S, Le Strat Y, Etain B, et al. Childhood trauma and perinatal depression: data from the IGEDEPP cohort. J Clin Psychiatry 2021 ; 82 : 13664.
De Paula Eduardo JAF, De Rezende MG, Menezes PR, et al. Preterm birth as a risk factor for postpartum depression: A systematic review and meta- analysis. J Affect Disord 2019 ; 259 : 392–403.
Tebeka S, Le Strat Y, Mandelbrot L, et al. Early- and late-onset postpartum depression exhibit distinct associated factors: the IGEDEPP prospective cohort study. BJOG 2021 ; 128 : 1683–93.
Underwood L, Waldie K, D’Souza S, et al. A review of longitudinal studies on antenatal and postnatal depression. Arch Womens Ment Health 2016 ; 19 : 711–20.
McIntosh AM, Sullivan PF, Lewis CM. Uncovering the genetic architecture of major depression. Neuron 2019 ; 102 : 91–103.
Howard DM, Adams MJ, Clarke T-K, et al. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci 2019 ; 22 : 343–52.
Viktorin A, Meltzer-Brody S, Kuja-Halkola R, et al. Heritability of perinatal depression and genetic overlap with nonperinatal depression. Am J Psychiatry 2016 ; 173 : 158–65.
Elwood J, Murray E, Bell A, et al. A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression. J Affect Disord 2019 ; 253 : 51–62.
Tebeka S, Gloaguen E, Mullaert J, et al. Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study. Eur Psychiatry J Assoc Eur Psychiatr 2024 ; 67 : 1–36.
Kiewa J, Meltzer-Brody S, Milgrom J, et al. Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non- perinatal depression. Depress Anxiety 2022 ; 39 : 182–91.
Pouget JG, Taylor VH, Dennis C-L, et al. Preliminary insights into the genetic architecture of postpartum depressive symptom severity using polygenic risk scores. Pers Med Psychiatry 2021 ; 27-8 : 100081.
Zhong M, Zhang H, Yu C, et al. Application of machine learning in predicting the risk of postpartum depression: A systematic review. J Affect Disord 2022 ; 318 : 364–79.
Gidén K, Vinnerljung L, Iliadis SI, et al. Feeling better? - Identification, interventions, and remission among women with early postpartum depressive symptoms in Sweden: a nested cohort study. Eur Psychiatry J Assoc Eur Psychiatr 2024 ; 67 : e14.
Clifford BN, Eggum ND, Rogers A, et al. Mothers’ and fathers’ depressive symptoms across four years postpartum: An examination of between- and bidirectional within-person relations. J Affect Disord 2024 ; 351 : 560–8.
Doncarli A, Gorza M, Gomes E, et al. Perinatal suicide: Recent epidemiological data and prevention strategies. Bull Epidémiologique Hebd 2023.
Jahan N, Went TR, Sultan W, et al. Untreated depression during pregnancy and its effect on pregnancy outcomes: a systematic review. Cureus 2021 ; 13 : e17251.
Slomian J, Honvo G, Emonts P, et al. Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes. Womens Health 2019 ; 15 : 174550651984404.
Fan X, Wu N, Tu Y, et al. Perinatal depression and infant and toddler neurodevelopment: A systematic review and meta-analysis. Neurosci Biobehav Rev 2024 ; 159 : 105579.
Murray L, Arteche A, Fearon P, et al. Maternal postnatal depression and the development of depression in offspring up to 16 years of age. J Am Acad Child Adolesc Psychiatry 2011 ; 50 : 460–70.
Rao W-W, Zhu X-M, Zong Q-Q, et al. Prevalence of prenatal and postpartum depression in fathers: A comprehensive meta-analysis of observational surveys. J Affect Disord 2020 ; 263 : 491–9.
Kingston D, Tough S, Whitfield H. Prenatal and postpartum maternal psychological distress and infant development: a systematic review. Child Psychiatry Hum Dev 2012 ; 43 : 683–714.
Goodman JH. Perinatal depression and infant mental health. Arch Psychiatr Nurs 2019 ; 33 : 217–24.
Levis B, McMillan D, Sun Y, et al. Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta-analysis. Int J Methods Psychiatr Res 2019 ; e1803.
Yang Y, Wang T, Wang D, et al. Gaps between current practice in perinatal depression screening and guideline recommendations: a systematic review. Gen Hosp Psychiatry 2024 ; 89 : 41–8.
Vigod SN, Frey BN, Clark CT, et al. Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l’humeur, des troubles anxieux et des troubles connexes périnatals. Can J Psychiatry Rev Can Psychiatr 2025 ; 70 : 429–89.
Lewkowitz AK, Whelan AR, Ayala NK, et al. The effect of digital health interventions on postpartum depression or anxiety: a systematic review and meta-analysis of randomized controlled trials. Am J Obstet Gynecol 2024 ; 230 : 12–43.
Postpartum Depression: Action towards causes and treatment (PACT) consortium. heterogeneity of postpartum depression: a latent class analysis. Lancet Psychiatry 2015 ; 2 : 59–67.
Pawluski JL, Lonstein JS, Fleming AS. The neurobiology of postpartum anxiety and depression. Trends Neurosci. 2017 ; 40 : 106–20.
Tebeka S, Gauld C, Belzeaux R, et al. Major depressive episode and postpartum depression: A network analysis comparison on the IGEDEPP cohort. Eur Psychiatry J Assoc Eur Psychiatr 2023 ; 66 : e51.
Woody CA, Ferrari AJ, Siskind DJ, et al. A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J Affect Disord 2017 ; 219 : 86–92.
Bhat A, Nanda A, Murphy L, et al. A systematic review of screening for perinatal depression and anxiety in community-based settings. Arch Womens Ment Health 2022 ; 25 : 33–49.
Shorey S, Chee CYI, Ng ED, et al. Prevalence and incidence of postpartum depression among healthy mothers: A systematic review and meta-analysis. J Psychiatr Res 2018 ; 104 : 235–48.
Kothari C, Wiley J, Moe A, et al. Maternal depression is not just a problem early on. Public Health 2016 ; 137 : 154–61.
Wikman A, Axfors C, Iliadis SI, et al. Characteristics of women with different perinatal depression trajectories. J Neurosci Res 2020 ; 98 : 1268–82.
Tebeka S, Le Strat Y, De Premorel Higgons A, et al. Prevalence and incidence of postpartum depression and environmental factors: The IGEDEPP cohort. J Psychiatr Res 2021 ; 138 : 366–74.
Qiu W, Hodges TE, Clark EL, et al. Perinatal depression: Heterogeneity of disease and in animal models. Front Neuroendocrinol 2020 ; 59 : 100854.
Meltzer-Brody S, Larsen JT, Petersen L, et al. Adverse life events increase risk for postpartum psychiatric episodes: A population-based epidemiologic study. Depress Anxiety 2018 ; 35 : 160–7.
Yin X, Sun N, Jiang N, et al. Prevalence and associated factors of antenatal depression: Systematic reviews and meta-analyses. Clin Psychol Rev 2021 ; 83 : 101932.
Doncarli A, Tebeka S, Demiguel V, et al. Prévalence de la dépression, de l’anxiété et des idées suicidaires à deux mois post-partum : données de l’Enquête nationale périnatale 2021 en France hexagonale. 2023.
Dlamini LP, Amelia VL, Shongwe MC, et al. Antenatal depression across trimesters as a risk for postpartum depression and estimation of the fraction of postpartum depression attributable to antenatal depression: A systematic review and meta-analysis of cohort studies. Gen Hosp Psychiatry 2023 ; 85 : 35–42.
American Psychiatric Association. DSM-5 : diagnostic and statistical manual of mental disorders, 5th edition. 2013 : 1275 p.
Stewart DE, Vigod S. Postpartum depression. N Engl J Med 2016 ; 375 : 2177–86.
Xiao M, Hu Y, Huang S, et al. Prevalence of suicidal ideation in pregnancy and the postpartum: A systematic review and meta-analysis. J Affect Disord 2022 ; 296 : 322–36.
Xiao M, Fu B, Huang S, et al. Trajectories of perinatal suicidal ideation from early pregnancy to six weeks postpartum and their influencing factors: A prospective longitudinal study. Psychiatry Res 2023 ; 328 : 115467.
Tebeka S, Godin O, Mazer N, et al. Clinical characteristics of bipolar disorders with postpartum depressive onset. Prog. Neuropsychopharmacol. Biol Psychiatry 2021 ; 107 : 110225.
Liu X, Agerbo E, Li J, et al. Depression and anxiety in the postpartum period and risk of bipolar disorder: a danish nationwide register-based cohort study. J Clin Psychiatry 2017 ; 78 : e469–76.
Norhayati MN, Hazlina NHN, Asrenee AR, et al. Magnitude and risk factors for postpartum symptoms: a literature review. J Affect Disord 2015 ; 175 : 34–52.
Landman A, Ngameni EG, Dubreucq M, et al. Postpartum blues: a predictor of postpartum depression, from the IGEDEPP Cohort. Eur Psychiatry J Assoc Eur Psychiatr 2024 ; 67 : e30.
Rezaie-Keikhaie K, Arbabshastan ME, Rafiemanesh H, et al. Systematic review and meta-analysis of the prevalence of the maternity blues in the postpartum period. JOGNN 2020 ; 49 : 127–36.
Perry A, Gordon-Smith K, Di Florio A, Craddock N, et al. Mood episodes in pregnancy and risk of postpartum recurrence in bipolar disorder: The Bipolar Disorder Research Network Pregnancy Study. J Affect Disord 2021 ; 294 : 714–22.
Stewart DE, Vigod SN. Postpartum depression: pathophysiology, treatment, and emerging therapeutics. Annu Rev Med 2019 ; 70 : 183–96.
Tebeka S, Le Strat Y, Dubertret C. Developmental trajectories of pregnant and postpartum depression in an epidemiologic survey. J Affect Disord 2016 ; 203 : 62–8.
Hutchens BF, Kearney J. Risk factors for postpartum depression: an umbrella review. J Midwifery Womens Health 2020 ; 65 : 96–108.
Tebeka S, Le Strat Y, Etain B, et al. Childhood trauma and perinatal depression: data from the IGEDEPP cohort. J Clin Psychiatry 2021 ; 82 : 13664.
De Paula Eduardo JAF, De Rezende MG, Menezes PR, et al. Preterm birth as a risk factor for postpartum depression: A systematic review and meta- analysis. J Affect Disord 2019 ; 259 : 392–403.
Tebeka S, Le Strat Y, Mandelbrot L, et al. Early- and late-onset postpartum depression exhibit distinct associated factors: the IGEDEPP prospective cohort study. BJOG 2021 ; 128 : 1683–93.
Underwood L, Waldie K, D’Souza S, et al. A review of longitudinal studies on antenatal and postnatal depression. Arch Womens Ment Health 2016 ; 19 : 711–20.
McIntosh AM, Sullivan PF, Lewis CM. Uncovering the genetic architecture of major depression. Neuron 2019 ; 102 : 91–103.
Howard DM, Adams MJ, Clarke T-K, et al. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci 2019 ; 22 : 343–52.
Viktorin A, Meltzer-Brody S, Kuja-Halkola R, et al. Heritability of perinatal depression and genetic overlap with nonperinatal depression. Am J Psychiatry 2016 ; 173 : 158–65.
Elwood J, Murray E, Bell A, et al. A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression. J Affect Disord 2019 ; 253 : 51–62.
Tebeka S, Gloaguen E, Mullaert J, et al. Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study. Eur Psychiatry J Assoc Eur Psychiatr 2024 ; 67 : 1–36.
Kiewa J, Meltzer-Brody S, Milgrom J, et al. Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non- perinatal depression. Depress Anxiety 2022 ; 39 : 182–91.
Pouget JG, Taylor VH, Dennis C-L, et al. Preliminary insights into the genetic architecture of postpartum depressive symptom severity using polygenic risk scores. Pers Med Psychiatry 2021 ; 27-8 : 100081.
Zhong M, Zhang H, Yu C, et al. Application of machine learning in predicting the risk of postpartum depression: A systematic review. J Affect Disord 2022 ; 318 : 364–79.
Gidén K, Vinnerljung L, Iliadis SI, et al. Feeling better? - Identification, interventions, and remission among women with early postpartum depressive symptoms in Sweden: a nested cohort study. Eur Psychiatry J Assoc Eur Psychiatr 2024 ; 67 : e14.
Clifford BN, Eggum ND, Rogers A, et al. Mothers’ and fathers’ depressive symptoms across four years postpartum: An examination of between- and bidirectional within-person relations. J Affect Disord 2024 ; 351 : 560–8.
Doncarli A, Gorza M, Gomes E, et al. Perinatal suicide: Recent epidemiological data and prevention strategies. Bull Epidémiologique Hebd 2023.
Jahan N, Went TR, Sultan W, et al. Untreated depression during pregnancy and its effect on pregnancy outcomes: a systematic review. Cureus 2021 ; 13 : e17251.
Slomian J, Honvo G, Emonts P, et al. Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes. Womens Health 2019 ; 15 : 174550651984404.
Fan X, Wu N, Tu Y, et al. Perinatal depression and infant and toddler neurodevelopment: A systematic review and meta-analysis. Neurosci Biobehav Rev 2024 ; 159 : 105579.
Murray L, Arteche A, Fearon P, et al. Maternal postnatal depression and the development of depression in offspring up to 16 years of age. J Am Acad Child Adolesc Psychiatry 2011 ; 50 : 460–70.
Rao W-W, Zhu X-M, Zong Q-Q, et al. Prevalence of prenatal and postpartum depression in fathers: A comprehensive meta-analysis of observational surveys. J Affect Disord 2020 ; 263 : 491–9.
Kingston D, Tough S, Whitfield H. Prenatal and postpartum maternal psychological distress and infant development: a systematic review. Child Psychiatry Hum Dev 2012 ; 43 : 683–714.
Goodman JH. Perinatal depression and infant mental health. Arch Psychiatr Nurs 2019 ; 33 : 217–24.
Levis B, McMillan D, Sun Y, et al. Comparison of major depression diagnostic classification probability using the SCID, CIDI, and MINI diagnostic interviews among women in pregnancy or postpartum: An individual participant data meta-analysis. Int J Methods Psychiatr Res 2019 ; e1803.
Yang Y, Wang T, Wang D, et al. Gaps between current practice in perinatal depression screening and guideline recommendations: a systematic review. Gen Hosp Psychiatry 2024 ; 89 : 41–8.
Vigod SN, Frey BN, Clark CT, et al. Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l’humeur, des troubles anxieux et des troubles connexes périnatals. Can J Psychiatry Rev Can Psychiatr 2025 ; 70 : 429–89.
Lewkowitz AK, Whelan AR, Ayala NK, et al. The effect of digital health interventions on postpartum depression or anxiety: a systematic review and meta-analysis of randomized controlled trials. Am J Obstet Gynecol 2024 ; 230 : 12–43.
Contributed Indexing:
Local Abstract: [Publisher, French] Dépression périnatale - Une pathologie fréquente, aux enjeux majeurs pour la santé des femmes. [Publisher, French] La dépression périnatale est une maladie fréquente, touchant 10 à 20 % des femmes après un accouchement. Souvent sous-diagnostiquée, elle peut avoir de lourdes conséquences pour la mère, l’enfant et le couple. Cette synthèse aborde l’épidémiologie, les facteurs de risque et les spécificités sémiologiques. Elle insiste sur l’importance d’un dépistage systématique, d’une évaluation spécialisée, et d’une prise en charge graduée alliant traitements pharmacologiques, non pharmacologiques et un travail pluridisciplinaire.
Entry Date(s):
Date Created: 20260106 Date Completed: 20260106 Latest Revision: 20260106
Update Code:
20260107
DOI:
10.1051/medsci/2025238
PMID:
41494071
Database:
MEDLINE
Weitere Informationen
Perinatal depression is a common condition that concerns 10 to 20 % of women after childbirth. Often underdiagnosed, it has significant consequences for the mother's mental health, the child's development, and family dynamics. This review explores its epidemiology, risk factors, and distinct clinical manifestations. It highlights the need for systematic screening, expert assessment, and a stepped approach to care that integrates pharmacological and non-pharmacological interventions within a coordinated multidisciplinary framework.
(© 2025 médecine/sciences – Inserm.)