Treffer: Fractal-shaped droplet microfluidics for highly scalable cell mechanoporation.

Title:
Fractal-shaped droplet microfluidics for highly scalable cell mechanoporation.
Authors:
Sung M; Department of Bioengineering, Korea University, 02841 Seoul, Republic of Korea.; Interdisciplinary Program in Precision Public Health (PPH), Korea University, 02841 Seoul, Republic of Korea., Jing D; School of Mechanical Engineering, University of Shanghai for Science and Technology, 200240 Shanghai, China.; School of Engineering and Materials Science, Queen Mary University of London, E1 4NS London, UK., Joo B; Department of Bioengineering, Korea University, 02841 Seoul, Republic of Korea.; MxT Biotech, 04785 Seoul, Republic of Korea., Im S; MxT Biotech, 04785 Seoul, Republic of Korea., Kim YJ; Department of Bioengineering, Korea University, 02841 Seoul, Republic of Korea.; Interdisciplinary Program in Precision Public Health (PPH), Korea University, 02841 Seoul, Republic of Korea., Sui Y; School of Engineering and Materials Science, Queen Mary University of London, E1 4NS London, UK., Chung AJ; Department of Bioengineering, Korea University, 02841 Seoul, Republic of Korea.; Interdisciplinary Program in Precision Public Health (PPH), Korea University, 02841 Seoul, Republic of Korea.; MxT Biotech, 04785 Seoul, Republic of Korea.; School of Biomedical Engineering, Korea University, 02841 Seoul, Republic of Korea. ac467@korea.ac.kr.
Source:
Lab on a chip [Lab Chip] 2026 Jan 06; Vol. 26 (1), pp. 10-17. Date of Electronic Publication: 2026 Jan 06.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE
Imprint Name(s):
Original Publication: Cambridge, UK : Royal Society of Chemistry, c2001-
MeSH Terms:
Microfluidic Analytical Techniques*/instrumentation , Microfluidic Analytical Techniques*/methods , Fractals* , Lab-On-A-Chip Devices*, Humans ; Cell Survival ; Cell Engineering/instrumentation ; Equipment Design
Entry Date(s):
Date Created: 20251210 Date Completed: 20260106 Latest Revision: 20260106
Update Code:
20260107
DOI:
10.1039/d5lc00865d
PMID:
41370109
Database:
MEDLINE

Weitere Informationen

Emerging non-viral gene delivery platforms provide alternatives to viral methods. However, they remain limited in scalability and efficiency for clinical translation. We present a fractal-shaped droplet microfluidic system that achieves approximately 98% efficiency and 80% viability at throughputs exceeding 10 <sup>7</sup> cells per min, enabling efficient, large-scale, and clinically relevant cell engineering.