Treffer: Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models.

Title:
Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models.
Authors:
Afzal S; Department of Biomedical Engineering (Medicine), Shenzhen University, Shenzhen, 518060, Guangdong, China.; Shenzhen Hospital, Shenzhen, Guangdong, China., Khan S; Qarshi Herb Research Center at Qarshi Industries (Pvt.) Ltd, Haripur, Hattar, Pakistan.; Qarshi University, Lahore, 54000, Pakistan., Ammarullah MI; Department of Mechanical Engineering, Faculty of Engineering, Universitas Diponegoro, Semarang, 50275, Central Java, Indonesia.; Undip Biomechanics Engineering & Research Centre (UBM-ERC), Universitas Diponegoro, Semarang, 50275, Central Java, Indonesia.; Bioengineering and Environmental Sustainability Research Centre, University of Liberia, Monrovia, 1000, Montserrado, Liberia.
Source:
Open medicine (Warsaw, Poland) [Open Med (Wars)] 2025 Jun 03; Vol. 20 (1), pp. 20241092. Date of Electronic Publication: 2025 Jun 03 (Print Publication: 2025).
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: De Gruyter Open Country of Publication: Poland NLM ID: 101672167 Publication Model: eCollection Cited Medium: Print ISSN: 2391-5463 (Print) NLM ISO Abbreviation: Open Med (Wars) Subsets: PubMed not MEDLINE
Imprint Name(s):
Original Publication: Warsaw, Poland : De Gruyter Open, [2015]-
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Contributed Indexing:
Keywords: Apteranthes tuberculata; animal studies; antioxidant activity; extraction methods; phytochemical analysis
Entry Date(s):
Date Created: 20250609 Latest Revision: 20250611
Update Code:
20250611
PubMed Central ID:
PMC12144909
DOI:
10.1515/med-2024-1092
PMID:
40486925
Database:
MEDLINE

Weitere Informationen

Background: This study comprehensively analyzes the pharmacological effects of ethanolic extract of Apteranthes tuberculata (EEAT) on various physiological parameters in mice.
Objective: The research aimed to quantify flavonoid and phenol contents across different extraction methods, with a focus on the superior efficacy of the ethanolic extract.
Methods: In vitro assays were conducted to assess the antioxidant activity of EEAT, revealing dose-dependent effects and significant inhibition percentages.
Results: EEAT exhibited notable analgesic effects in the writhing response test, particularly at 200 mg/kg, indicating its potential as a natural analgesic. Additionally, its anti-inflammatory effects were complex and dose-dependent in a carrageenan-induced paw edema model. The extract also showed significant changes in body temperature regulation following Brewer's yeast-induced fever, revealing a distinct pattern of initial hypothermia followed by gradual re-elevation. Furthermore, EEAT demonstrated regulatory effects on gastrointestinal motility, with higher doses enhancing intestinal transit in charcoal meal tests.
Conclusion: This study highlights the pharmacological potential of EEAT as a natural therapeutic agent for antioxidant, analgesic, anti-inflammatory, and gastrointestinal regulation, warranting further investigation into its mechanisms of action and therapeutic applications.
(© 2025 the author(s), published by De Gruyter.)

Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.