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Treffer: Numerical Modeling and Computer Simulation of a Meander Line Antenna for Alzheimer's Disease Treatment, a Feasibility Study.

Title:
Numerical Modeling and Computer Simulation of a Meander Line Antenna for Alzheimer's Disease Treatment, a Feasibility Study.
Authors:
Perez FP; Department of Medicine, Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA., Rahmani M; Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA., Morisaki J; Department of Bioengineering, University of Illinois at Chicago, Chicago, USA., Amran F; Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA., Bakri S; Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA., Halim A; Department of Bioengineering, University of Illinois at Chicago, Chicago, USA., Dsouza A; Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA., Yusuff NM; Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA., Farhan A; Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA., Maulucci J; Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA., Rizkalla M; Department of Electrical and Computer Engineering, Indiana University-Purdue University, Indianapolis, USA.
Source:
Journal of biosciences and medicines [J Biosci Med (Irvine)] 2023 Feb; Vol. 11 (2), pp. 177-185.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Scientific Research Publishing, Inc Country of Publication: United States NLM ID: 101686921 Publication Model: Print Cited Medium: Print ISSN: 2327-5081 (Print) Linking ISSN: 23275081 NLM ISO Abbreviation: J Biosci Med (Irvine) Subsets: PubMed not MEDLINE
Imprint Name(s):
Original Publication: Irvine, CA : Scientific Research Publishing, Inc.
References:
J Biomed Sci. 2022 Jun 13;29(1):39. (PMID: 35698225)
Electromagn Biol Med. 2015 Sep;34(3):180-2. (PMID: 26444190)
J Biomed Sci Eng. 2017 Sep;10(9):421-430. (PMID: 28959376)
PLoS One. 2015 Apr 22;10(4):e0124126. (PMID: 25901747)
J Biomed Sci Eng. 2022 May;15(5):129-139. (PMID: 35663520)
Sci Rep. 2021 Jan 12;11(1):621. (PMID: 33436686)
Grant Information:
UL1 TR000006 United States TR NCATS NIH HHS
Contributed Indexing:
Keywords: Alzheimer’s Disease; EMF Linearity; Field Distribution; HFSS; Meander Line Antenna; SAR
Entry Date(s):
Date Created: 20230322 Latest Revision: 20230328
Update Code:
20250114
PubMed Central ID:
PMC10026125
DOI:
10.4236/jbm.2023.112013
PMID:
36945328
Database:
MEDLINE

Weitere Informationen

Alzheimer's disease (AD) is a brain disorder that eventually causes memory loss and the ability to perform simple cognitive functions; research efforts within pharmaceuticals and other medical treatments have minimal impact on the disease. Our preliminary biological studies showed that Repeated Electromagnetic Field Stimulation (REFMS) applying an EM frequency of 64 MHz and a specific absorption rate (SAR) of 0.4 - 0.9 W/kg decrease the level of amyloid- β peptides (A β ), which is the most likely etiology of AD. This study emphasizes uniform E/H field and SAR distribution with adequate penetration depth penetration through multiple human head layers driven with low input power for safety treatments. In this work, we performed numerical modeling and computer simulations of a portable Meander Line antenna (MLA) to achieve the required EMF parameters to treat AD. The MLA device features a low cost, small size, wide bandwidth, and the ability to integrate into a portable system. This study utilized a High-Frequency Simulation System (HFSS) in the design of the MLA with the desired characteristics suited for AD treatment in humans. The team designed a 24-turn antenna with a 60 cm length and 25 cm width and achieved the required resonant frequency of 64 MHz. Here we used two numerical human head phantoms to test the antenna, the MIDA and spherical head phantom with six and seven tissue layers, respectively. The antenna was fed from a 50-Watt input source to obtain the SAR of 0.6 W/kg requirement in the center of the simulated brain tissue layer. We found that the E/H field and SAR distribution produced was not homogeneous; there were areas of high SAR values close to the antenna transmitter, also areas of low SAR value far away from the antenna. This paper details the antenna parameters, the scattering parameters response, the efficiency response, and the E and H field distribution; we presented the computer simulation results and discussed future work for a practical model.

Conflicts of Interest The authors declare no conflicts of interest regarding the publication of this paper.