• A hierarchical cellular struct...

Treffer: A hierarchical cellular structural model to unravel the universal power-law rheological behavior of living cells.

Title:
A hierarchical cellular structural model to unravel the universal power-law rheological behavior of living cells.
Authors:
Hang JT; Laboratory for Multiscale Mechanics and Medical Science, Department of Engineering Mechanics, SVL, School of Aerospace Engineering, Xi'an Jiaotong University, 710049, Xi'an, China., Kang Y; College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China., Xu GK; Laboratory for Multiscale Mechanics and Medical Science, Department of Engineering Mechanics, SVL, School of Aerospace Engineering, Xi'an Jiaotong University, 710049, Xi'an, China. guangkuixu@mail.xjtu.edu.cn., Gao H; School of Mechanical and Aerospace Engineering, College of Engineering, Nanyang Technological University, 639798, Singapore, Singapore. huajian.gao@ntu.edu.sg.; Institute of High Performance Computing, A*STAR, 138632, Singapore, Singapore. huajian.gao@ntu.edu.sg.
Source:
Nature communications [Nat Commun] 2021 Oct 18; Vol. 12 (1), pp. 6067. Date of Electronic Publication: 2021 Oct 18.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
English
Journal Info:
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Imprint Name(s):
Original Publication: [London] : Nature Pub. Group
MeSH Terms:
Models, Structural* , Rheology*, Cytoplasm/*physiology , Cytoskeleton/*physiology, Cell Membrane ; Models, Theoretical
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Entry Date(s):
Date Created: 20211019 Date Completed: 20211117 Latest Revision: 20211117
Update Code:
20250114
PubMed Central ID:
PMC8523554
DOI:
10.1038/s41467-021-26283-y
PMID:
34663821
Database:
MEDLINE

Weitere Informationen

Living cells are a complex soft material with fascinating mechanical properties. A striking feature is that, regardless of their types or states, cells exhibit a universal power-law rheological behavior which to this date still has not been captured by a single theoretical model. Here, we propose a cellular structural model that accounts for the essential mechanical responses of cell membrane, cytoplasm and cytoskeleton. We demonstrate that this model can naturally reproduce the universal power-law characteristics of cell rheology, as well as how its power-law exponent is related to cellular stiffness. More importantly, the power-law exponent can be quantitatively tuned in the range of 0.1 ~ 0.5, as found in most types of cells, by varying the stiffness or architecture of the cytoskeleton. Based on the structural characteristics, we further develop a self-similar hierarchical model that can spontaneously capture the power-law characteristics of creep compliance over time and complex modulus over frequency. The present model suggests that mechanical responses of cells may depend primarily on their generic architectural mechanism, rather than specific molecular properties.
(© 2021. The Author(s).)